News History Research Faculty Training Opportunities Job Openings Administration Links



CHANNING LABORATORY NEWS




New book on respiratory genetics from Channing co-authors Drs. Scott Weiss and Edwin Silverman
HPCGG Helix Newsletter, December, 2005



Scott Weiss, M.D., M.S. and Edwin Silverman, M.D., Ph.D., noted Channing scientists have co-authored a new book entitled "Respiratory Genetics". The book provides an introduction to the major fields and genetic approaches to respiratory disorders and provides an integrated discussion of progress in genetics of both common and rare respiratory diseases in a comprehensive fashion.





* * *

Channing scientists publish exciting new breakthrough study on blocking growth of adhesions after surgery
The Harvard Focus, December 16, 2005

     Channing scientists, Dr. Begonia Ruiz-Perez, HMS instructor in medicine at Brigham and Women's Hospital, and Dr. Arthur Tzianabos, former HMS associate professor of medicine (microbiology and molecular genetics) at BWH, and collaborators have released results of research that could lead to new treatments for inflammatory response suppression. Click HERE to read more of this new weapon against adhesions.

* * *

Channing scientist, Dr. Arnold Chan, will participate in new HSPH award
The Harvard Gazette, December 1, 2005

     Dr. Arnold Chan, Channing Laboratory and HSPH Department of Epidemiology scientist, will be collaborating in a new $30 Million five-year grant studying the long-term effects of children of antiretroviral (ART) drugs administered to their pregnant mothers with the hope of preventing mother-to-infant transmission of HIV. Click HERE to read about this important new study.

* * *

Channing scientist and colleagues publish two new versions of the DASH diet
by Amanda Gardner, HealthDay Reporter, November 16, 2005

     Dr. Frank Sacks, respected Channing Scientist and one of the authors of the government's DASH (Dietary Approaches to Stop Hypertension) diet, have introduced two new modified versions of the original diet. The new diet shifts about 10 percent of calories from carbohydrates to either protein-rich foods or to monounsaturated fats such as olive or canola oil. Click HERE to read about these important new developments in this pioneering study. Also see Harvard University Gazette's announcement of November 17, 2005 regarding this long term study.

* * *

Honors and Advances
The Harvard Focus, November 11, 2005

     Well-known Channing associate scientist, Dr. JoAnn Manson, the Elizabeth F. Brigham professor of women's health at HMS and Brigham and Women's Hospital, has received the NIH's Robert S. Gordon, Jr. Lectureship Award for her outstanding research on women's health, including her work on the Women's Health Initiative.

* * *

THREE CHANNING LABORATORY SCIENTISTS ARE AMONG THE TEN MOST FREQUENTLY CITED RESEARCHERS IN THE COUNTRY!!

The Boston Globe, October 10, 2005

Dr. Meir Stampfer Dr. Walter Willett Dr. Graham Colditz

It is with great pride we here at Channing Laboratory make the following announcement:

     In today's Globe it was reported that Dr. Meir Stampfer, renowned Channing scientist and professor at the Harvard School of Public Health is the most frequently cited researcher in the country, according to ISI Essential Science Indicators, a research tracking company. Dr. Walter Willett, chairman of the Department of Nutrition at HSPH and another well-known Channing researcher was the No. 2 most quoted Channing researcher. Dr. Graham Colditz, head of the prestigious Nurses' Health Study headquartered here at the Channing and professor of epidemiology at Brigham and Women's Hospital was listed as No. 7.

These scientists reflect the high level of dedication the research community has come to expect from Channing Laboratory and we extend our heartiest congratulations to each of them on a superb record of accomplishments.

* * *

Respected Channing researcher Dr. Richard Platt and colleagues receive important grant from CDC
The Harvard Focus, October 14, 2005



     Dr. Richard Platt, co-principal investigator Dr. Kenneth Mandl, and other Boston-based consortium groups, have received a $4.5 million grant from the CDC to build a CDC Center of Excellence in Public Health Informatics. Dr. Platt will focus on dealing with clinician-public health interactions and will create medical-record software to allow secure communication between doctors and public health officials. Click HERE to read more about this ground-breaking effort.




* * *

Women's Health Grants Announced
The Harvard Focus, September 30, 2005

     The HMS Center of Excellence in Women's Health has awarded the following new research grants to several Channing scientists:

Experience of Violence in Childhood Adolescence in Lesbian, Bisexual, and Heterosexual Women in the Nurses' Health Study II

     S. Bryn Austin, HSPH assistant professor in the Department of Society, Human Development, and Health and HMS assistant professor of pediatrics at Children's Hospital Boston (Principal Investigator), and Rosalind J. Wright, HMS assistant professor of medicine at Brigham and Women's Hospital and HSPH assistant professor in the Department of Society, Human Development, and Health (Co-principal Investigator).

Pilot Studies of Plasma Proteomic Profiling as a Tool for Studies of Ovarian Cancer Risk

Shelley Tworoger, HMS instructor in Medicine at BWH (Principal Investigator), and Dimitrios Spentzos, HMS instructor in medicine at BID (Co-principal Investigator)

* * *

Honors and Advances
The Harvard Focus, September 30, 2005

     Mei-Ling Ting Lee, HMS associate professor of medicine (biostatistics) at Brigham and Women's Hospital and HSPH associate professor in the Department of Biostatistics, was inducted as a fellow of the Institute of Mathematical Statistics on August 8 at the Joint Statistical Meetings in Minneapolis. Lee received the award for her significant theoretical contributions to distribution theory and biostatistics, her development of innovative statistical models and methodology for survival data analysis, and her overall professional service to mathematical statistics.

* * *

Channing scientist named chair of HSPH's Department of Environmental Health

The Harvard Focus,Bulletin, September 30, 2005

     Dr. Douglas Dockery, esteemed Channing scientist, has HSPH professor of environmental epidemiology and HMS associate professor of medicine (epidemiology), was named chair of HSPH's Department of Environmental Health, effective Sept. 1. Dr. Dockery is internationally known for his innovative work in environmental epidemiology, most recently in pursuing the biological mechanisms underlying the relationship between air pollution and acute cardiovascular mortality and morbidity. He was one of the principal investigators of the renowned Six Cities Study of Air Pollution and Health, which had a major impact on air quality standards for particulate air pollution.

* * *

Well known Channing scientist, Dr. Walter Willett, wins Bristol-Myers/Mead Johnson award.
The Harvard Gazette, September 15, 2005

     
Frederick John Stare Professor of Epidemiology and Nutrition Walter C. Willett received the 25th annual Bristol-Myers Squibb/Mead Johnson Freedom to Discover Award for Distinguished Achievement in Nutrition Research this past August. An independent panel selected Willett, who is also the chairman of the Department of Nutrition in the Faculty of Public Heatlth, and a professor of medicine at Harvard Medical School.
Willett was recognized for his pioneering work in the field of nutritional epidemiology, including the development of large-scale cohort studies and methods to assess dietary intake in large populations.

* * *

Kasper Applies Expertise to Standardize Biosecurity
Who's News

The BWH Bulletin, August 12, 2005

     Dennis Kasper, MD, director of the Channing Laboratory in the Department of Medicine, will chair a 24-member committee charged by the federal Department of Health and Human Services to recommend strategies for oversight of federally conducted or supported biological research that has the potential for dual use--that is, research yielding knowledge of public health benefit that could possibly be exploited by persons seeking to do harm. The National Science Advisory Board for Biosecurity (NSABB), which first met last month in Bethesda, MD, will consider both national security concerns and the needs of the research community. "It's an honor to be selected to chair this board, which includes so many distinguished members representing a broad spectrum of expertise from academia, the biotechnical industry and government," Kasper said. "It is a significant challenge we have ahead of us, but I think my colleagues on the board are up to this critical task of strategic development in this area of science."

     (For more information, visit www.biosecurity.com).

* * *

The Boston Globe, July 3, 2005, by Gareth Cook, Globe Staff      

     Dr. Scott Weiss, pioneering Channing Laboratory asthma researcher, is participating in a new $20 million dollar project to build a database capable of finding links between the DNA of a patient and many illnesses. Dr. Weiss, heading the first study carried out under the project guidelines, is seeking to identify a genetic signature shared by severe asthma patients who don't respond well to the usual treatments. If this theory holds true, with the help of the new database, this type of patient could be identified well in advance, saving much trial and error for both the patient and his physician. Obviously, genetic studies of this type could also be applied to identifying and treating patients with hypertension, type 2 diabetes, Huntington's disease, or a host of other possible gene-related illnesses. Look for many more important studies in the future as medical research uses technology more and more in their quest for the answers to so many perplexing questions

* * *

Channing Laboratory Director Dr. Dennis Kasper and colleague Dr. Sarkis Mazmanian make an important new contribution to our knowledge of immune system development.

by Courtney Humphries, The Harvard Focus, July 15, 2005

     

In an article published in the July 15 Cell, Drs. Kasper, Mazmanian, and their team at the Channing report that B fragilis, a common intestinal bacterium, contributes to the development of the immune system, as well as help digestion, protect against infection, and contribute to the development of the intestine after birth. In a recent statement Dr. Kasper states "No one has previously described in mammalian systems a single molecule that causes symbiosis." He goes on to say, "If you look at my career and most of my colleagues' in the Microbiology Department, we've all spent our years studying pathogens. And here's an amazingly important biologic function--and it has nothing to do with a pathogen, but it does have to do with bacteria." Click HERE to read about this exciting newest contribution by the Channing Laboratory's team.

* * *

In The News

The BWH Bulletin, July 15, 2005

     Channing scientists, Catherine Berkey, Sc. D. and co-authors Walter Willett, M.D., Dr.PH, Graham Colditz, M.D., Dr.PH, and Harvard co-author Helaine Rockett, MS, RD, publish an important new study on adolescent weight gain and milk consumption. Results of the study won media attention from WCVB (Ch.5), WHDH (Ch. 7), and WLVI (Ch. 56) in Boston, and ABC News, as well as The Washington Post, Lost Angeles Times, Boston Herald, WebMD, and Reuters. The study concluded that children who drank more than three servings per day were 25 percent more likely to become overweight during a one-year period than those who drank two or three servings per day. According to the study, the extra weight gain is a likely outcome of the extra calories consumed, though most of the 12,000 children from all 50 states who participated in the study drank non-fat or low-fat milk. The study appeared in the June Archives of Pediatrics and Adolescent Medicine.

     In The News also references the important results of the recently published study [See the previous Channing News article of May 26] from Dr. Michelle Holmes and the Nurses' Health Study headquartered at the Channing in which Dr. Holmes discovered that women who walked at a moderate pace three to five hours a week are 50 percent less likely to die from breast cancer after being diagnosed with the disease. Coverage of this study was featured on Boston television, ABC's Good Morning America, The Boston Globe, The Wall Street Journal, Reuters, The LA Times, and USA Today.

* * *

The staff and employees here at Channing Laboratory wish to take this opportunity to welcome Joseph Loscalzo, MD, PhD, newly appointed chairman of the Department of Medicine. We look forward to continued growth and accomplishments in the research community both for the Channing and Brigham and Women's Hospital under his direction and guidance. Welcome, Dr. Loscalzo!!

* * *

BWH 2005 SERVICE AWARDS
The BWH Bulletin, June 2005

     The Channing Laboratory offers sincere congratulations to the following Channing employees for their years of service to BWH, recognized at the annual Service Award Program ceremony held June 9, 2005 at the Cabot Atrium, Brigham & Women's Hospital:


5 YEAR SERVICE AWARDS
  • Olga Henry Saturne
  • James Keary
10 YEAR SERVICE AWARDS
  • Soma Datta
  • Jennifer Hankins
  • Timothy Little
25 YEAR SERVICE AWARDS
  • Barbara A. Egan
  • Norman Stein

* * *

Drs. Graham Colditz, JoAnn Manson, and Frank Hu, nationally known Channing scientists, disagree with newest study from CDC on obesity and mortality rates
The Harvard University Gazette, June 2, 2005
by Alvin Powell, Harvard News Office

     
On May 26th last, HSPH sponsored an important forum to discuss the latest study published by Dr. Katherine M. Flegal , CDC scientist, stating that being somewhat overweight resulted in a slight reduction in mortality. Channing scientists, long known for their battle against the public bulge, publicly commented on the findings. Dr. Graham Colditz, respected head of the Nurses' Health Study headquartered at the Channing, expressed his concern that the study would give the public the wrong impression regarding the importance of controlling weight gain. Other Channing scientists, Dr. JoAnn Manson and Dr. Frank Hu, having worked on this issue extensively during their careers, also took exception to the results. Both stated their research has shown a clear correlation to obesity and higher mortality. Click HERE for a more detailed account of "Weighing the Evidence: A Forum to Examine the Latest News About Overweight, Obesity, and Mortality in America."

* * *

Respected Channing Laboratory scientist Dr. Michelle Holmes is lead author of an important new study appearing in the May 25 issue of the Journal of the American Medical Association on the importance of exercise in surviving breast cancer.
The Harvard University Gazette, May 26, 2005

     The study finds that physical activity after breast cancer diagnosis could possibly lower their risk of death from this most feared of diseases for women. Click HERE to read the results of this landmark study.

* * *

Drs. JoAnn Manson and Frank Hu take exception to the latest government study indicating overweight people who are fit may live longer than people of norman weight.
by Carol Cruzan Morton, The Harvard Focus, May 20, 2005

     In a paper coauthored by Drs. JoAnn Manson, Frank Hu, and HSPH scientists and published in the Dec. 23rd New England Journal of Medicine, findings show excessive weight and limited exercise are important indicators of early death. They reason that the public should not consider this a validation of obesity. Click HERE to read this relevant discussion of one of America's foremost health problems.

* * *

Dr. Hyon Choi, Instructor in Medicine at Harvard Medical School, and noted Channing scientists Dr. Frank Hu, Dr. Walter Willett, and Dr. Meir Stampfer co-author important new study of the consumption of low-fat dairy foods and the risk of men developing type 2 diabetes.
The Harvard University Gazette, May 12, 2005

     Using data compiled by the Health Professionals Follow-Up Study, the study evaluated information from over 41,000 professionals free of diabetes, cardiovascular disease, and/or cancer at the start of the study and supplementary surveys of those participants reporting the development of type 2 diabetes. The results indicated that men consuming higher levels of dairy products had a significantly lowered risk of developing the disease. Click HERE to read more on this important study.

* * *

CONGRATULATIONS

Channing Scientist Honored at Harvard Ceremony
The Harvard University Gazette, May 12, 2005

     At a ceremony and gala reception held today at Ropes-Gray Room, Pound Hall, Harvard Law School and hosted by Harvard's president Lawrence H. Summers, a valued member of the medical research community and Channing Laboratory scientist Dr. Catherine S. Berkey was honored for her 25 years service at Harvard University.

* * *

Esther K. Wei, HSPH Instructor and Channing Laboratory scientist, publishes interesting new study results linking Vitamin B6 to the reduction of colorectal cancer.

The Harvard University Gazette, May 5, 2005

     In the May 4 issue of the Journal of the National Cancer Institute, Dr. Wei and research colleagues, utilizing data from the Nurses' Health Study, also headquartered at the Channing, published the results of their study of risk factors for women developing colorectal cancer and the role of Vitamin B6. The researchers analyzed blood samples from over 32,000 females and observed that Vitamin B6 could possibly help reduce the risk of colorectal cancer in women. Click HERE to read the results of this first of its kind study.

* * *

Channing scientist, Dr. Richard Malley, and his colleague Marc Lipsitch have released the exciting findings of their newest study on fighting pneumococcus without antibodies
by Courtney Humphries, The Harvard Focus, April 26, 2005

     Dr. Richard Malley, HMS assistant professor of pediatrics at Children's Hospital, Boston, Dr. Marc Lipsitch, HSPH associate professor of epidemiology, and colleagues have recently published the findings of their latest study advocating a new approach to the battle against Streptococcus pneumoniae in the March 29 Proceedings of the National Academy of Sciences. This dreaded killer of the young and those with compromised immune systems has been rather successfully treated by newly developed vaccines producing antibodies but Dr. Malley's approach was to develop a different vaccine containing whole killed pneumonococcal cells stripped of their sugar coats. Click HERE to go to the Harvard Focus and read more about this potentially far-reaching study.

* * *

Newly published study by Channing scientists finds broad dietary patterns have no link to pancreatic cancer risk
The Harvard Focus, April 6, 2005

     Researchers Dominique Michaud, HSPH assistant professor of epidemiology and Charles Fuchs, HMS associate professor of medicine at the DFCI have published a study in the April 6 issue of the Journal of the National Cancer Institute, utilizing data from the Nurses' Health Study and the Health Professionals Follow-Up Study trying to find a match between Western diet and pancreatic cancer risk. The data analyzed surprisingly revealed no link between the two factors. Click HERE to go to the Harvard Focus and read more about this important study.

* * *

CONGRATULATIONS

Channing Scientist is Statistician of the Year
The Harvard Focus, March 25, 2005

     
Mei-Ling Ting Lee, HMS associate professor of medicine (biostatistics) and associate professor in the Department of Biostatistics at HSPH, was recognized as the "2005 Mosteller Statistician of the Year" by the Boston Area Chapter of the American Statistical Association at a dinner in her honor on February 16. The award was presented to Lee in recognition of her contributions to biostatistics and her service to the profession.




* * *

The Women's Health Initiative and BWH's Dr. Joann Manson find new test to predict heart attack.
The Harvard University Gazette, March 17, 2005

     Once again, Dr. Joann Manson, leader of the Women's Health Initiative at BWH, and her fellow researchers have contributed another weapon against one of the biggest killers in the U.S. The study found that the participants with elevated white blood cells had more than double the risk of fatal heart disease. Although the study only included women as participants, Dr. Manson feels strongly that the type of test could also be relevant for men. Click HERE and go to the Harvard Gazette's web page to read more about this breakthrough study.

* * *

Channing scientist, Dr. Lorelei Mucci, releases results of her newest study looking for breast cancer risks in acrylamide intake.
The Harvard University Gazette, March 17, 2005

     Dr. Mucci, along with colleagues from the HSPH and the Karolinska Institute of Stockholm, Sweden have finished a study looking for an association between the intake of the carcinogen acrylamide and breast cancer. The results, published in the March 16, 2005 issue of the Journal of the American Medical Association, showed no link between acrylamide intake in food to an increased risk of the cancer. To read more about this study, CLICK HERE.

* * *

Dr. Alberto Ascherio, respected Channing scientist, publishes important new study on Parkinson's disease
The Harvard University Gazette, February 24, 2005

     Parkinson's disease, a truly debilitating illness, usually strikes men after the age of 50 with devastating results. Dr. Ascherio's findings show that men who engage in strenuous physical activity in their younger years cut their risk of developing Parkinson's disease by 60 percent. Click HERE to read more about his important new study.

* * *

NEW BOOKS

The Winter Bookshelf

Dr. Joann Manson publishes new updated book.
The BWH Bulletin, February 11, 2005

JoAnn E. Manson, Julie E. Buring, Paul M. Ridker, J. Michael Gaziano
Clinical Trials in Heart Disease, Second Edition
Elsevier Saunders

     The recent discovery of cardiovascular risks associated with hormone replacement therapy have underscored the importance of large-scale clinical trials to assess treatments. Clinical Trials in Heart Disease, a companion text to Braunwald's Heart Disease for clinicians and researchers, reviews the methodologies, pitfalls, and interpretation of clinical trials and details current progress of treatment trials for conditions associated with cardiovascular disease. The text has been extensively updated with several new chapters and information, reflecting the explosion of new trials since the first edition was published in 1999. The book brings together HMS faculty members JoAnn Manson and Elizabeth Brigham, professor of women's health and professor of medicine; Julie Buring, professor of ambulatory care and prevention; Paul Ridker, the Eugene Braunwald professor of medicine; and J. Michael Gaziano, associate professor of medicine, all at Brigham and Women's Hospital.

* * *

CONGRATULATIONS

Channing Laboratory Director Receives High Honor
The BWH Bulletin, February 4, 2005

     The BWH-BRI announcement and panel discussion gave way to the presentation of this year's McArthur Research Service Award. The award, supported by the Susan, Katarina and Isabella McArthur Radovsky Endowment Fund, is presented annually to a member or members of the BWH research faculty who exemplify the spirit of community by volunteering time and effort to the members of our organization. The 2005 McArthur Award was presented to Frank Speizer, MD, co-director of BWH's Channing Lab and creator of the BWH's landmark Nurses' Health Study. "Frank's mentorship and contributions to research at BWH far exceed the walls of the Channing Lab,", said Michael Brenner, MD, chair of the Research Council and co-chair of the Research Institute Steering Committee.

* * *

CONGRATULATIONS

Channing Scientist is Honored for Length of Service
The BWH Bulletin, February 4, 2005

     

The Channing Laboratory wishes to extend warm congratulations to Dr. Walter Willett. Dr. Willett was also recognized at the eight annual BWH-BRI Research Report and Celebration for 25 years of service to BWH. Congratulations, Dr. Willett, on your many years of outstanding research from your friends here at the Channing.


* * *

Channing Scientists Study Physician Suicides
The Harvard University Gazette, February 3, 2005
by William J. Cromie, Harvard News Office

     
Channing scientists, Dr. Graham Colditz and Dr. Eva Schernhammer undertook a recent study of physician suicides and the surprising results left many new questions for future researchers. The study showed that suicide rate among female doctors was more than double the rate of the general public and that male doctors killed themselves at a rate 41 percent higher that that of other men and women. Click HERE to read more about this significant new study.


* * *

Channing Fellow Launches CD Effort for Tsunami Relief
The Harvard University Gazette, February 3, 2005

When he learned of Harvard's offer to match student and employee contributions to tsunami relief efforts, Harvard Medical School instructor Brian Cobb was ready to write a check. Then he wondered if, instead of giving $100, he might be able to make a larger donation with a little help from his friends.

     So Cobb, an immunology researcher who's also a songwriter, electric bass player, and vocalist, decided to launch a compilation CD and funnel all sales to the American Red Cross. With musical compatriot Barry Thompson, Cobb tapped the online community of followers of one of their favorite progressive rock bands, Spock's Beard. The duo has been overwhelmed by the response of artists willing to donate a song to The Tsunami Project.

     "It's ballooned almost out of proportion," says Cobb, adding that it's now a double CD set.

     Rick Wakeman, keyboardist of the band Yes, is the CD's biggest name; other contributors are signed artists or talented amateurs from around the United States and the world, says Cobb. He and Thompson plan to press 200 CDs, funded with their own money and donations from friends, and sell them at $15 each via a Web site. If they sell all 200 CDs, of which Cobb is fairly confident, they'll send $3000 to the American Red Cross's tsunami relief efforts.

     Cobb has no personal connection to tsunami-ravaged areas but was nontheless moved to action by the disaster. "The scale of this is so incredible...that every bit will help," he says. "This seemed like the least we could do. We've got music sitting around, and the CD gives people a reason to give beyond just being philanthropic."

12/27/05; Brian is no longer taking donations through his site.

* * *


BACK