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CHANNING LABORATORY NEWS
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CONGRATULATIONS
The many friends and colleagues of Dr. Frank Sacks, long time faculty member here at the Channing Laboratory, extend their hardiest congratulations on his appointment to Professor of Medicine at the Brigham and Women's Hospital.
The Harvard FOCUS, December 17, 2004
New Appointments to Full Professor
Frank Sacks
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Lead Raises Risk for Cataracts In a recent study, Channing Laboratory's Dr. Howard Hu and Harvard Medical School's Dr. Debra Schaumberg and colleagues revealed the first data ever collected relating lead toxicity to cataract. Click HERE to read more about this important new discovery.
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Postmarketing Study Answers Questions on Statin Safety Respected Channing scientist Dr. Richard Platt and colleagues have conducted an important new study on the safety and viability of the new stain drugs. Click HERE to visit the Harvard web site and read more about this important new study.
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Fine-Particle Pollution Linked to Blood Pressure Boost Channing Lab's respected scientist, Dr. Diane Gold and her project colleagues find link between fine-particle pollution and higher blood pressure. Click HERE to read more about this important study.
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Transplant Teams: Continuing a Tradition of Excellence Channing Laboratory proudly recognizes the participation of two of its most dedicated scientists, Dawn DeMeo, M.D. and Anne Fuhlbrigge, M.D., M.P.H., both members of the thoracic transplant team at BWH, in record breaking multiple lung transplants performed this month. Click HERE to read more about this exciting team.
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CONGRATULATIONS
The Harvard FOCUS, October 1, 2004
Channing Laboratory wishes to extend its sincere congratulations to Channing faculty member Dr. David Hunter on his appointment as Vincent L. Gregory Professor of Cancer Prevention in the Departments of Epidemiolgoy and Nutrition, Harvard School of Public Health.
Hunter heads the recently established Program in Molecular and Genetic Epidemiology at HSPH and has worked toward improving understanding of the causes of cancer, particularly that of the breast, colon, and skin. He is an investigator on the Nurses' Health Study and is project director for the Nurses' Health Study II. Hunter is also the director of the Dana-Farber/Harvard Cancer Center Polymorphism Detection Core that provides genetyping facilities for investigators at HSPH and in the Longwood area.
The Channing also wishes to extend hearty congratulations to former Channing associate Dr. Raphael Dolin on his appointment as Maxwell Finland Professor of Medicine (Microbiology and Molecular Genetics), Beth Israel Deaconess Medical Center. Dolin, also a Harvard Medical School dean for academic and clinical programs, has a longstanding interest in laboratory and clinical investigations of viral pathogenesis, antiviral chemotherapy, and viral vaccines. He and his colleagues were the first to describe the Norwalk, Hawaii, and Snow Mountain viruses of gastroenteritis and to investigate the pathophysiology of disease caused by these agents in humans. He has conducted large-scale clinical trials of antiviral drugs such as acyclovir, rimantadine, and didanosine as well as studies of live attenuated influenza virus and rotavirus vaccines. Dolin's current research interest is the development and clinical study of candidate AIDS vaccines, and he is the prinicipal investigator of the NIAID-sponsored HIV Vaccine Trials Unit at HMS.
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In The News In a groundbreaking study published in the Archives of Internal Medicine, Gary Curhan, MD, found that pain relievers containing acetaminophen, such as Tylenol®, might cause a decline in kidney function. This important consumer health information was reported on CNN and in US News and World Report, The Boston Globe, Boston Herald, MSNBC, and The Washington Post.
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In The News In response to a blockbuster Journal of the American Medical Association study on sugared beverages and their link to diabetes, JoAnn Manson, MD, MPH, was interviewed by WCVB-TV (Ch. 5), and New England Cable News.
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Sugary Drinks, Obesity, and Type 2 Diabetes
by Carol Cruz Morton
The Harvard FOCUS, September 3, 2004 Respected Channing faculty member, Dr. Frank Hu and his Harvard colleagues, utilizing data from Channing Labortory-based Nurses' Health Study II, release study results showing the first definite link between sugar-sweetened beverages and type 2 diabetes and obesity. Click HERE to read more about this fascinating new research effort.
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ANNOUNCEMENT
The Harvard FOCUS, September 3, 2004
Harvard Medical School has announced that Channing Co-Director Dr. Elliott Kieff will step down as director of The Program in Virology after 13 years. Dr. Kieff's successor, Dr. David Knipe, the Higgins professor of microbiology and molecular genetics, has been appointed the director of the Graduate Program in Virology at HMS and the Graduate School of Arts and Sciences. "The Program inVirology has grown and flourished under the leadership of Elliott Kieff," Knipe said.
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Multivitamins help with AIDS treatment
by Stu Hutson
The Harvard FOCUS, July 16, 2004
Channing Laboratory faculty member Dr. David Hunter and HSPH's Dr. Wafaie Fawzi during a study of HIV-infected women in Dar es Salaam, Tanzania, discovered that vitamin supplements helped slow the progress of the disease. Click HERE to read more about this new discovery.
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The Truth on Foods and Fats
The U.S. News & World Report, July 12, 2004
Congratulations to Channing Laboratory's Dr. Walter Willett, world famous diet and health researcher, on his recognition by U.S. News & World Report as a Pioneer of Medicine. Click HERE to read about Dr. Willett's many contributions to the study of nutrition and diet over the course of his prolific career.
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Congratulations to Channing Laboratory faculty member Dr. Ichiro Kawachi, on receiving Harvard University's Faculty Teaching Excellence Citation
The Harvard FOCUS, June 25, 2004
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BWH 2004 SERVICE AWARDS The Channing Laboratory offers sincere congratulations to the following Channing employees for their years of service to BWH, recognized at the annual Service Award Program ceremony held June 10, 2004 at the Cabot Atrium, Brigham & Women's Hospital: * * *
MEDIA NOTES
BWH Bulletin, June 18, 2004 Dr. Gary Curhan's study on kidney stones grabbed the attention of many major media outlets. New York Newsday, The Boston Herald, The Boston Globe, New England Cable News and Reuters all covered the study, which found that intake of foods rich in calcium and phytate may decrease the risk of kidney stones in younger women. The study was published in the Archives of Internal Medicine.
Researcher Eunyoung Cho, Sc. D., published two large-scale studies this spring, both of which made media splashes. Her paper from the Annals of Internal Medicine on alcohol and colorectal cancer was featured in The Boston Herald and The Washington Post. A recent JAMA Archives paper on fruit and a common eye disease among older adults was featured on WBZ Ch. 4, BBC, CNN radio, WCBS radio and was covered by Reuters.
Leveraging data from the landmark Nurses' Health Study, BWH researcher Candyce Kroenke, MPH and ScD, reported on two important findings that shed new light on the risk and impact of breast cancer on women. The first study, in the Journal of Clinical Oncology, found that women 40-years-old and younger were more likely to be negatively impacted by physical, social and psychological issues than older women struggling with the disease. In a second study published in the American Journal of Epidemiology, researchers found that stress induced by caregiving did not increase breast cancer risk. Both studies received broad media coverage including Channel 4 and the Boston Globe
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The Channing Laboratory wishes to extend a warm welcome to Marc A. Pfeffer, M.D., Ph.D., our new acting Chairman of the Department of Medicine. Dr. Pfeffer, long respected in the medical community for his work in Cardiology, brings many years of experience in medical administration to the research community. Welcome, Dr. Pfeffer!
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Channing Laboratory wishes to extend hearty congratulations to Dr. Victor Dzau, former Chairman of the Department of Medicine at Brigham and Women's Hospital, on his appointment to the position of Chancellor at Duke University. Dr. Dzau has been a staunch supporter of the Channing during his tenure at BWH and his contributions and standards of excellence will be truly missed. Best of luck, Dr. Dzau.
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Scott Weiss, M.D., M.S., respected Channing scientist, makes new headway in improving diagnosis and treatment of COPD and asthma
Scott Weiss, M.D., M.S., Professor of Medicine, HMS and Associate Director of the HPCGG, has grown our Channing Laboratory into the world leader in the study of the genetics and epidemiology of COPD and asthma. The seriousness of this work to improve the diagnosis and treatment of these irreversible and many times fatal diseases is even more urgent today. Since 1980 asthma cases have increased 80 percent in the US with no end in sight. Click HERE to read more about the new research efforts to conquer these severe respiratory disorders.
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New evidence that fruit may help reduce blindness afflicting the elderly.
by Alvin Powell, Harvard News Office
The Harvard University Gazette, June 17, 2004
Dr. Eunyoung Cho, along with Channing scientists Dr. Walter Willett, Dr. Bernard Rosner, Dr. Susan Hankinson, and many Harvard Medical School and Harvard School of Public Health colleagues, have found a link between the amount of fruit servings per day and the reduction of the risk of developing Neovascular Age-related Maculopathy (ARM), a disease resulting in progressive loss of sight common to many elderly patients. Data for the study was obtained from the Nurses' Health Study and the Health Professionals Follow-Up Study. Click HERE to read more about the amazing results of the study.
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Announcing a new Publication by Channing Laboratory scientist Mei-Ling Ting Lee.
Analysis of Microarray Gene Expression Data, Kluwer Academic Publishers
The Harvard FOCUS, June 4, 2004
Large-scale measurement of gene expression using DNA microarrays presents special challenges in data collection and analysis. Lee, an HMS associate professor of medicine (biostatistics) at Channing Laboratory and Brigham and Women's Hospital, has written this book to provide readers with an integrated treatment of various topics in this evolving field. After a primer on array techniques and a consideration of experimental design and data collection, the bulk of the book covers common statistical methods used to analyze gene expression. Subjects covered include ANOVA models, permutation tests, and Bayesian methods, as well as unsupervised exploratory analysis and supervised learning methods.
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Channing Co-Director Dr. Dennis Kasper, Dr. Brian Cobb, and colleagues discover role of carbohydrates in fighting disease through vaccines and antimicrobial therapies.
by Misia Landau
The Harvard FOCUS, June 4, 2004 Channing Laboratory's Co-Director Dr. Dennis Kasper, Dr. Brian Cobb, HMS research fellow in microbiology and molecular genetics, and colleagues make an important new discovery in immune cell research. In their most recent study, Drs. Kasper, Cobb, and associated scientists show that carbohydrates, never before considered as T-cell activators, actually are taken in by the cell and follow the same MHC II processing pathway as protein antigens. Click HERE to read more about this exiting new breakthrough in immune research.
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Harvard researchers and Channing Laboratory scientist Dr. Karin Michels present one more reason to count those calories.
by William J. Cromie, Harvard News Office
The Harvard University Gazette, June 3, 2004
Dr. Karin Michels, innovative Channing Lab scientist, and her Harvard colleagues, using data from several Swedish databases, have taken another step in proving that counting those calories can be beneficial in fighting long term diseases such as breast cancer. Click HERE to read more about this informative new study.
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Channing Laboratory faculty member Dr. Diane Feskanich finds new smoking risk evidence.
The Harvard University Gazette, June 3, 2004
Dr. Diane Feskanich has found new evidence that both men and women with similar smoking histories have the same risk of lung cancer. Click HERE to read more about this newest challenge to the popular medical belief that women are more susceptible than men to lung cancer risk.
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Dr. Candyce H. Kroenke studies the role of chronic stress in breast cancer.
The Harvard University Gazette, June 3, 2004
Contrary to popular thought, Channing Laboratory researcher, Dr. Candyce H. Kroenke, using data from the BWH Nurses' Health Study has delivered some surprising results from her latest study on stress as a risk factor in the development of breast cancer. Click HERE to read more about her findings.
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The Harvard Gazette, May 13, 2004
Congratulations to Channing Laboratory faculty member Dr. Eric Garshick , honored by Harvard University for 25 years of service, at a reception on May 13, 2004 at the Ropes-Gray Room, Pound Hall, Harvard Law School.
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Channing Associate Scientist, Dr. JoAnn Manson, Elizabeth F. Brigham professor of women's health at HMS and Brigham and Women's, releases important news on hormone therapy for older women.
If you are an older woman in her 60s and 70s, this news is really important. Dr. JoAnn Manson, Channing Laboratory associate scientist, has published the results of the estrogen-only arm of the Women's Health Initiative, six weeks after the trial was prematurely halted due to extra risks of stroke for the participants. Click HERE to read Dr. Manson's views on the risks of hormone therapy.
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Channing Laboratory faculty member, Dr. Karen Michels, releases the results of her new study on calorie restriction and breast cancer.
Dr. Karen Michels, after investigation of more than 7000 anorexic Swedish women, was able to measure for the first time the effect of severe calorie restriction on breast cancer incidence in women. Click HERE to read about this timely and far-reaching study.
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Respected Channing Laboratory associate, Dr. JoAnn Manson, releases the results of her recent study of biomarkers identifying inflammation that is an underlying risk factor for diabetes and cardiovascular disease.
Type 2 diabetes, the most common form of diabetes in the U.S., affects approximately 17 million of our citizens. After analyzing data from the Nurses' Health Study, Dr. JoAnn Manson and colleagues have made an important advance in the search for diagnostic tools for this killer disease. Click HERE to read about the results of her most recent study.
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Dr. JoAnn Manson, Channing Laboratory associate scientist, presents detailed HRT study results.
The Women's Health Initiative (WHI), after studying over 10,000 women across the country for over 6.8 years, has determined that "estrogen-alone" HRT (Hormone Replacement Therapy) increased the risk of stroke. Click HERE to read a more detailed description of the study results.
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Channing Co-Director Dennis L. Kasper and Channing Faculty Member Michael Farzan hold free seminar on emerging infectious diseases.
If the words "West Nile virus, SARS," or emerging infectious disease" send you scurrying for one of those natty surgical masks, an evening that the folks at Harvard Medical School have dreamed up could be for you.
On Wednesday, three experts from the faculty -- Darren Higgins, PhD; Michael Farzan, PhD, and Dennis Kasper, MD -- will offer a free Longwood Seminar that will fill you in on everything you ever wanted to know, and quite possibly a whole lot more, about the infectious diseases of the future. Billed as "Bug alert: Emerging infectious disease," the program will explore not only how scientists go about tracking these emerging "bugs," but also the latest on biosecurity and a peek into some intriguing research Harvard has going.
And not to worry: Since the start time is 5:30 p.m. in the New Research Building, 77 Avenue Louis Pasteur, you should be out by 7, leaving time to stop by the store for some infection-fighting, immunity-boosting antioxidants.
To reserve a spot, visit www.hms.harvard.edu/longwood_seminars or call 617-432-3038.
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Channing Laboratory associate scientists publish important new research findings linking inflammation markers to type 2 diabetes
In a study published in the March issue of Diabetes, Drs. JoAnn Manson and Frank Hu revealed that the highest levels of C-reactive protein (CRP), formerly more associated with cardiovascular disease, also may be a link to diagnosing high risk of type 2 diabetes. Click HERE to read about this important new research.
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