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Lorelei Mucci, Ph.D.

Assistant Professor of Medicine
Harvard Medical School

Associate Professor of Epidemiology
Harvard School of Public Health

Associate Epidemiologist, Department of Medicine
Brigham and Women's Hospital

Research Interests

Dr. Mucci received her doctoral training in epidemiology from the Harvard School of Public Health, and received further training in cancer epidemiology as a post-doctoral fellow at the Karolinska Institutet in Sweden and then at the Harvard School of Public Health. At present, her primary research areas are: 1-) Dietary acrylamide and cancer risk and 2-) Epidemiology of prostate cancer.

Dietary acrylamide and risk of cancer

In April 2002, the Swedish National Food Administration reported elevated levels of the substance acrylamide, a probable human carcinogen, in several commonly consumed foods, including breads, cereals, potato products and coffee. Using epidemiological data from Sweden, Dr. Mucci is analyzing data from population-based case-control studies and cohort studies, to examine whether intake of acrylamide in foods increases the risk of cancer of the large bowel, bladder, kidney, breast or prostate.

Epidemiology of prostate cancer

Working with Dr. Meir Stampfer and Dr. Jing Ma, Dr. Mucci is involved in several related studies to identify molecular predictors of prostate cancer incidence and survival within the Physicians Health Study (PHS) and Health Professionals Follow-up Study (HPFS), in which more than 5,500 cases of prostate cancer have been documented. She is also actively involved in a population-based cohort of 1,500 prostate cancer cases from Sweden who have undergone “watchful waiting” as treatment. An important focus of this work is to develop molecular models, in combination with clinical parameters, that can be translated in the clinical setting to distinguish aggressive prostate cancer from indolent disease. The US and Swedish projects to evaluate molecular predictors of prostate cancer survival are being undertaken in concert with the DF/HCC Prostate Cancer SPORE, of which she is an active participant.

Selected Publications

Mucci LA, Tamimi R, Lagiou P, Trichopoulou A, Benetou V, Spanos E, Trichopoulos D. Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system? BJU Int. 2001;87(9):814-20. [abstract]

Mucci LA, Granath F, Cnattingius S. Maternal smoking and childhood leukemia and lymphoma risk among 1,440,542 Swedish children. Cancer Epidemiol Biomarkers Prev. 2004;13(9):1528-33. [abstract]

Mucci LA, Lindblad P, Steineck G, Adami HO. Dietary acrylamide and risk of renal cell cancer. Int J Cancer. 2004;109(5):774-6. [abstract]

Rubin MA, Bismar TA, Andrén O, Mucci L, Kim R, Shen R, Ghosh D, Wei JT, Chinnaiyan AM, Adami HO, Kantoff PW, Johansson JE. Decreased Alpha-Methylacyl CoA racemase Expression in Localized Prostate Cancer is Associated with an Increased Rate of Biochemical Recurrence and Cancer Specific Death. Cancer Epidemiol Biomarker Prev. 2005;14(6):1424-32. [abstract]

Mucci LA, Sandin S, Bälter K, Adami HO, Magnusson C, Weiderpass E. Acrylamide intake and breast cancer risk in Swedish women. JAMA. 2005;293(11):1326-7. [abstract]