Biostatistician, Department of Medicine
Brigham and Women's Hospital

mei-ling.lee@channing.harvard.edu

Dr. Lee works on several areas of biostatistical applications. One area is collaborative research in microbiology. The microflora of the vaginal environment significantly affects the host's general state of health by acting as a biological barrier to infectious agents. In the past few years we have developed statistical methods that predict the interactions between microorganisms within the vaginal ecosystem.

The other area is research on statistical methods related to the analysis of longitudinal blood pressure measurements, the relationship of blood pressure to cardiovascular death, and the analysis of intra-person variation in patient compliance and blood pressure control. Dr. Lee also works on environmental and genetic epidemiologic research.

Dr. Lee is the Editor-in-Chief of an international journal, Lifetime Data Analysis, which is devoted to statistical methods and applications for time-to-event data.

D'Agostino RB, Lee MLT, Belanger AJ, Cupples LA, Anderson K, Kannel WB. Relation of pooled logistic regression to time-dependent Cox regression analysis: the Framingham Heart Study. Statistics in Medicine 1990;9:1501-15. [abstract]

Lee MLT, Ross RA, Delaney ML, Onderdonk AB. Predicting abnormal microbial population levels in the vaginal ecosystem. Microbial Ecology in Health and Diseases 1994;7:235-40.

Jewell NP, Kimber AC, Lee MLT, Whitmore GA eds. Lifetime Data: Models in reliability and surivial analysis. 1995 Kluwer Academic Publishers: Dordrecht, Netherlands.

Cole BF, Lee MLT, Whitmore GA, Zaslavsky AM. An empirical Bayes model for Markov dependent binary sequences with randomly missing observations. J Am Stat Assn 1995;25:324-328.

Lee MLT, Ross RA, Onderdonk AB. Cluster analysis of vaginal microflora data. Microecology and Therapy 1995;25:324-328.

Lee MLT, Rosner BA, Vokonas PS, Weiss ST. Longitudinal analysis of adult male blood pressure: the Normative Aging Study, 1963-1992. J Epidemiol Biostat 1996;1:79-87.

Lee MLT, Lazarus R. Meta analysis for drug safety data with logistic regressions. Drug Info J 1997;31:1189-1193.

Hougaard P, Lee MLT, Whitmore GA. Analysis of overdispersed count data by mixtures of Poisson variables and Poisson processes. Biometrics 1997;53:1225-1238. [abstract]

Lee MLT, Ross RA, Onderdonk AB. Statistical models for vaginal microflora: identifying women at risk for group B Streptococcus colonization as a test of concept. Infect Dis Obstet Gyn 1997;5:336-340.

Lee MLT, DuBois A, Ross RA, Onderdonk AB. Nonlinear models for in vitro kill kinetics of antibiotics. J Biopharmaceutical Stat 1999;18:529-533. [abstract]

Lee MLT, Rosner BA, Weiss ST. Relationship of blood pressure to cardiovascular death: the effects of pulse pressure in the elderly. Ann Epidemiol 1999;9:101-7. [abstract]

Lee MLT, Whitmore GA. Statistical inference for serial dilution assay data. Biometrics 1999; 55(4): 1215-1220. [Abstract]

Lee MLT, Rosner BA, Weiss ST, Vokonas PS, Gaziano JM. Predictors of cardiovascular deaths: the Normative Aging Study, 1963-1998. Clinical Geriatrics (in press).

Lee MLT, DeGruttola V, Schoenfeld D. A model for markers and latent health status. Journal of Royal Statistical Association, Series B, 2000; 62: 747-762.

Lee MLT, Kuo FC, Whitmore GA, Sklar J. Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridization. Proceedings of the National Academy of Sciences, USA, 2000; 97: 9834-9839. [Abstract]

Lee MLT, Schoenfeld D, Wang X, Penfornis A, Faustman D. Baynesian analysis of case control polygenic etiology studies with missing data. Biostatistics, 2001; 2: 309-322.

Lee MLT, Rosner BA. The average area under correlated ROC curves: a nonparametric approach based on generalized two-sample Wilcoxon statistics. Journal of Royal Statistical Society, series C, Applied Statistics, 2001; 50: 337-344.

Lee MLT, Lu W, Whitmore GA, Beier D. Models for microarray gene expression data. Journal of Biopharmaceutical Statistics, 2002; 12: 1-19. [Abstract]

Lee MLT, Bulyk ML, Whitmore GA, Church GM. A statistical model for investigating binding probability of DNA nucleotide sequences using microarrays. Biometrics, 2002; 58: 81-988. [Abstract]

Lee MLT, Whitmore GA. Power and sample size for microarray studies. Statistics in Medicine, 2002; 21: 3543-3570. [Abstract]