Associate Epidemiologist
Brigham and Women's Hospital

jiali.han@channing.harvard.edu

My research interests are breast and skin cancer genetic susceptibility and etiology, DNA repair and related molecular pathways, and ultraviolet exposures. I am interested in understanding the influence of genetic and environmental exposures in cancer etiology and prevention, particularly breast and skin cancer. I am currently engaged in working on inherited susceptibility, particularly focusing on DNA repair and related pathways. The skin cancer research includes melanoma, squamous cell carcinoma, and basal cell carcinoma. I continue to pursue my interest in genetic susceptibility to skin cancer and am examining additional candidate molecular pathways. Beyond the candidate gene approach, I am conducting a genome-wide association study on certain phenotypes. In addition to genetic susceptibility research, I am also interested in understanding the role of ultraviolet exposures (artificial and natural) in disease etiology in various populations.

Han J, Hankinson SE, De Vivo I, Colditz GA, Hunter DJ. No association between a stop codon polymorphism in RAD52 and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2002; 11(10):1138-9. No abstract available.

Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi R, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Res. 2003;63(23):8536-41. [abstract]

Han J, Hankinson SE, Hunter DJ, De Vivo I. Genetic variations in XRCC2 and XRCC3 are not associated with endometrial cancer risk. Cancer Epidemiol Biomarkers Prev. 2004;13(2):330-1. No abstract available.

Han J, Hankinson SE, Ranu H, De Vivo I, Hunter DJ. Polymorphisms in DNA double strand break repair genes and breast cancer risk in the Nurses’ Health Study. Carcinogenesis. 2004 Feb;25(2):189-95. Epub 2003 Oct 24. [abstract]

Han J, Colditz GA, Samson LD, Hunter DJ. Polymorphisms in DNA double strand break repair genes and skin cancer risk. Cancer Res . 2004;64(9):3009-13. [abstract]

Han J, Hankinson SE, Colditz GA, Hunter DJ. Genetic variation in XRCC1, sun exposure, and risk of skin cancer. Br J Cancer. 2004;91(8):1604-9. [abstract]

Han J, Hankinson SE, Zhang S, De Vivo I, Hunter DJ. Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2004;13:520-4. [abstract]

Han J, Colditz GA, Liu JS, Hunter DJ. Genetic variation in XPD, sun exposure, and risk of skin cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(6):1539-44. [abstract]

Han J, Colditz GA, Hunter DJ. Lack of associations between selected variants of genes involved in cell cycle and apoptosis and skin cancer risk. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):592-3. No abstract available.

Han, J, Tranah GJ, Hankinson SE, Samson LD, Hunter DJ. Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk. Pharmacogenet Genomics. 2006 Jul;16(7):469-474. [abstract]

Han J, Cox DG, Colditz GA, Hunter DJ. The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women. Mol Carcinog. 2006 Sep;45(9):694-700. [abstract]

Han J, Kraft P, Colditz GA, Wong J, Hunter DJ. Melanocortin 1 receptor variants and skin cancer risk. Int J Cancer. 2006 Oct 15;119(8):1976-84. [abstract]

Han J, Hankinson SE, De Vivo I. Polymorphisms in 06-methylguanine DNA methyltransferase and endometrial cancer risk. Carcinogenesis. 2006 Nov;27(11):2281-5. Epub 2006 Jun 15. [abstract]

Han J, Colditz GA, Hunter DJ. Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study. Int J Epidemiol. 2006 Dec;35(6):1514-21. Epub 2006 Aug 30. [abstract]

Han J, Colditz GA, Hunter DJ. Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Carcinogenesis. 2007 Feb;28(2):390-7. Epub 2006 Aug 31. [abstract]

Han J, Colditz GA, Hunter DJ. Manganese superoxide dismutase polymorphism and risk of skin cancer. Cancer Causes and Control. 2007;18(1):79-89. [abstract]

Zhang Y, Holford TR, Leaderer B, Zahm SH, Boyle P, Zhu Y, Wang R, Zou K, Zhang B, Flynn S, Han J, Zheng T. Ultraviolet radiation exposure and risk of non-Hodgkin's lymphoma in Connecticut women. Am J Epidemiol. 2007 Jun 1;165(11):1255-64. Epub 2007 Feb 26. [abstract]

Haiman CA, Hsu C, deBakker P, Frasco M, Sheng X, VanDenBerg D, Casagrande JT, Kolonel LN, LeMarchand L, Hankinson SE, Han J, Dunning AM, Pooley KA, Freedman ML, Hunter DJ, Wu AH, Stram DO, Henderson BE. Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations. Hum Mol Genet. 2008;17(6):825-34. Epub 2007 Dec 3. [abstract]

Han J, Kraft P, Nan H, Guo Q, Chen C, Qureshi A, Hankinson SE, Hu FB, Duffy DL, Zhao ZZ, Martin NG, Montgomery GW, Hayward NK, Thomas G, Hoover RN, Chanock S, Hunter DJ. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet. 2008;4(5):e1000074. [abstract]

Nan H, Qureshi AA, Hunter DJ, Han J. Interaction between p53 codon 72 polymorphism and elanocortin 1 receptor variants on suntan response and cutaneous melanoma risk. Br J Dermatol. 2008 Aug;159(2):314-21. Epub 2008 May 28. [abstract]

Gu F, Qureshi AA, Kraft P, Guo Q, Hunter DJ, Han J. Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Melanoma Res. 2008 Oct;18(5):330-5. [abstract]

Han J, Haiman C, Niu T, Guo Q, Cox DG, Willett WC,Hankinson SE, Hunter DJ. Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk. Breast Cancer Res Treat. 2008 Jun 13. [Epub ahead of print]. [abstract]

Nan H, Niu T, Hunter DJ, Han J. Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3551-7. [abstract}

He C, Tamimi RM, Hankinson SE, Hunter DJ, Han J. A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. Breast Cancer Res Treat. 2009 Feb;113(3):585-94. Epub 2008 Mar 14. [abstract]

Han J, Qureshi AA, Prescott J, Quo Q, Ye L, Hunter DJ, De Vivo I. A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol. 2009 Feb;129(2):415-21. Epub 2008 Jul 31. [abstract]

Gao X, Simon KC, Han J, Schwarzschild MA, Ascherio A. Genetic determinants of hair color and Parkinson's disease risk. Ann Neurol. 2009 Jan;65(1):76-82. [abstract]

Nan H, Qureshi AA, Hunter DJ, Han J. A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer. Cancer Causes Control. 2009 Mar;20(2):171-9. Epub 2008 Sep 24. [abstract]

Nan H, Kraft P, Qureshi A, Guo Q, Chen C, Hankinson SE, Hu FB, Thomas G, Hoover RN, Chanock S, Hunter DJ, Han J. Genome-wide association study of tanning phenotype in a population of European ancestry. J. Invest Dermatol. 2009; accepted.

Nan H, Kraft P, Hunter DJ, Han J. Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer. Int J Cancer 2009. Accepted.

Gu F, Qureshi AA, Kraft P, Guo Q, Hunter DJ, Han J. Polymorphisms in genes of DNA repair, cell growth, and oxidative stress and melanoma risk. Br J Dermatol. 2009. Accepted.