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Eric Garshick, MD

Associate Professor of Medicine
Harvard Medical School

Associate Chief,
Pulmonary and Critical Care
Section, VA Boston Healthcare System

Physician
Brigham and Women's Hospital

eric.garshick@channing.harvard.edu or eric.garshick@va.gov


Research Interests

Dr. Garshick's research interests are in two main areas (1) assessing the health effects of diesel and vehicle exhaust exposures, and (2) assessing risk factors and the natural history of chronic disease in persons with chronic spinal cord injury.

Health Effects of Diesel Exhaust

Dr. Garshick has lead two NIH-funded epidemiologic studies assessing relationships between lung cancer and diesel exhaust, and other outcomes including chronic respiratory and cardiovascular disease. The first study is a continuation of the mortality follow-up of the US Railroad Workers Study. The second study is a retrospective epidemiologic study among unionized trucking industry workers in the US. The major aims of the trucking industry study is to improve methods of defining past exposures to diesel exhaust using detailed work history records, extensive exposure monitoring and historical records. Current research includes an NIH funded field study assessing current exposures in the trucking industry and their relationships to biomarkers of exposure, inflammatory biomarkers, and gene expression.

Chronic Disease in Persons with Chronic Spinal Cord Injury (SCI)

Dr. Garshick has directed the VA Boston SCI Study since 1994 where he has assessed cross-sectional and longitudinal determinants of pulmonary function and respiratory illness in a large cohort of persons with SCI. The purpose of this research is to provide information regarding factors, if modified, might result in an improvement in pulmonary function and a reduction in respiratory morbidity and mortality in chronic SCI. Current research has focused on studying relationships between circulating inflammatory markers and pulmonary function. With other investigators in the VA Boston SCI cohort, he is also assessing risk factors for osteoporosis in SCI. This includes defining longitudinal relationships between circulating adipokines, central fat, and longitudinal decline in bone mineral density at the proximal femur and distal tibia, a common site of fracture in SCI. The VA Boston SCI studies are funded by the Department of Veterans Affairs and NIH.


Selected Publications

Garshick E, Schenker MB, Muñoz A, Segal M, Smith TJ, Woskie SR, Hammond SK, Speizer FE. A case-control study of lung cancer and diesel exhaust exposure in railroad workers. Am Rev Respir Dis. 1987 Jun;135(6):1242-8. [Abstract]

Garshick E, Schenker MB, Muñoz A, Segal M, Smith TJ, Woskie SR, Hammond SK, Speizer FE. A retrospective cohort study of diesel exhaust exposure and lung cancer in railroad workers. Am Rev Respir Dis. 1988 Apr;137(4):820-5. [abstract]

Garshick E, Laden F, Hart JE, Caron A. Residence near a major road and respiratory symptoms in US veterans. Epidemiology. 2003 Nov;14(6):728-36. [abstract]

Garshick E, Laden F, Hart JE, Rosner B, Smith TJ, Dockery DW, Speizer FE. Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect. 2004 Nov;112(15):1539-43. [abstract]

Garshick E, Laden F, Hart JE, Moy ML. Respiratory symptoms and intensity of occupational dust exposure. Int Arch Occup Environ Health. 2004 Oct;77(7):515-20. Epub 2004 Sep 10. [abstract]

Garshick E, Kelley A, Cohen SA, Garrison A, Tun CG, Gagnon D, Brown R. A prospective assessment of mortality in chronic spinal cord injury. Spinal Cord. 2005 Jul;43(7):408-16. [abstract]

Garshick E, Laden F, Hart JE, Smith TJ, Rosner B. Smoking imputation and lung cancer in railroad workers exposed to diesel exhaust. Am J Ind Med. 2006 Sep;49(9):709-18. [abstract]

Stolzmann KL, Gagnon DR, Brown R, Tun CG, Garshick E. Longitudinal change in FEV1 and FVC in chronic spinal cord injury. Am J Respir Crit Care Med. 2008 Apr 1;177(7):781-6. Epub 2008 Jan 17. [abstract]

Morse LR, Stolzmann KL, Nguyen HP, Jain NB, Zayac C, Gagnon DR, Tun CG, Garshick E. Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury. Arch Phys Med Rehabil. 2008 Apr;89(4):726-31. [abstract]

Garshick E, Laden F, Hart JE, Smith TJ, Rosner B , Davis ME, Eisen EA, Smith TJ. Lung cancer and vehicle exhaust in trucking industry workers. Environ Health Perspect. 2008 Oct;116(10):1327-32. Epub 2008 May 30. [abstract]

Waddimba AC, Jain NB, Stolzmann K, Gagnon DR, Burgess JF Jr, Kazis LE, Garshick E. Predictors of cardiopulmonary hospitalization in chronic spinal cord injury. Arch Phys Med Rehabil. 2009 Feb;90(2):193-200. [abstract]

Morse LR, Giangregorio L, Battaglino RA, Holland R, Craven BC, Stolzmann KL, Lazzari AA, Sabharwal S, Garshick E. VA Based Survey of Osteoporosis Management in Spinal Cord Injury. PM R. 2009 Mar;1(3):240-4. Epub 2009 Feb 6. [abstract]

Hart JE, Laden F, Eisen E, Smith TJ, Garshick E. Chronic obstructive pulmonary disease mortality in railroad workers. Occup Environ Med. 2009 Apr;66(4):221-6. Epub 2008 Nov 27. [abstract]