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Gary C. Curhan, M.D., Sc.D.

Professor of Medicine
Harvard Medical School

Brigham and Women's Hospital

Research Interests

Dr. Curhan is a member of the Channing Laboratory and the Renal division at the Brigham and Women's Hospital. Major funded active research interests include the epidemiology of nephrolithiasis, risk factors for renal function decline, cardiovascular disease, health effects of analgesic use, novel risk factors for hypertension, epidemiology of gout, and incontinence. Additional areas of active research include epidemiological studies of acute renal failure, pneumonia, painful bladder syndrome, and shingles. Risk factors being explored include dietary intake, 24-hour urine composition, urine and blood biomarkers, and genetic factors. Dr. Curhan spends approximately 80% of his time on these research activities and the remainder of his time on mentoring, teaching and co-directing parts of the PASTEUR program at HMS. He is the Editor-in-Chief for the Clinical Journal of the American Society of Nephrology (CJASN). He serves on national committees including the Advisory Council for the National Center for Complementary and Alternative Medicine at NIH.

Selected Publications

Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med. 1993 Mar 25;328(12):833-8. [abstract]

Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Twenty-four-hour urine chemistries and the risk of kidney stones among women and men. Kidney Int. 2001 Jun;59(6):2290-8. [abstract]

Dedier J, Stampfer MJ, Hankinson SE, Willett WC, Speizer FE, Curhan GC. Nonnarcotic analgesic use and the risk of hypertension in US women. Hypertension. 2002 Nov;40(5):604-8; discussion 601-3. [Abstract]

Knight EL, Stampfer MJ, Hankinson SE, Spiegelman D, Curhan GC. The impact of protein intake on renal function decline in women with normal renal function or mild renal insufficiency. Ann Intern Med. 2003 Mar 18;138(6):460-7. [abstract]

Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine-rich foods, dairy and protein intake, and risk of gout in men. N Engl J Med. 2004 Mar 11;350(11):1093-103. [abstract]

Curhan GC, Knight EL, Rosner B, Hankinson SE, Stampfer MJ. Lifetime nonnarcotic analgesic use and decline in renal function in women. Arch Intern Med. 2004 Jul 26;164(14):1519-24. [abstract]

Forman JP, Rimm EB, Stampfer MJ, Curhan GC. Folate intake and the risk of incident hypertension among US women. JAMA. 2005 Jan 19;293(3):320-9. [abstract]

Taylor EN, Stampfer MJ, Curhan GC. Obesity, weight gain, and the risk of kidney stones. JAMA. 2005 Jan 26;293(4):455-62. [abstract]

Tonelli M, Sacks F, Pfeffer M, Jhangri GS, Curhan GC; cholesterol and Recurrent Events (CARE) Trial Investigators. Biomarkers of inflammation and progression of chronic kidney disease. Kidney Int. 2005 Jul;68(1):237-45. [abstract]

Tonelli M, Isles C, Craven T, Tonkin A, Pfeffer MA, Shepherd J, Sacks FM, Furberg C, Cobbe SM, Simes J, West M, Packard C, Curhan GC. Effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease. Circulation. 2005 Jul 12;112(2):171-8. Epub 2005 Jul 5. [abstract]

Forman JP, Stampfer MJ, Curhan GC. Non-narcotic analgesic dose and risk of incident hypertension in US Women. Hypertension. 2005 Sep;46(3):500-7. Epub 2005 Aug 15. [abstract]

Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G; Cholesterol and Recurrent Events (CARE) Trial Investigators. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation. 2005 Oct; 112(17:2627-33. [abstract]

Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in Women. JAMA. 2005 Nov 9;294(18):2330-5. [Abstract]

Tonelli M, Keech A, Shepherd J, Sacks F, Tonkin A, Packard C, Pfeffer M, Simes J, Isles C, Furberg C, West M, Craven T, Curhan G. Effect of pravastatin in people with diabetes and chronic kidney disease. J Am Soc Nephrol. 2005 Dec;16(12):3748-54. Epub 2005 Oct 26. [abstract]

Taylor EN, Hu FB, Curhan GC. Antihypertensive medications and the risk of incident type 2 diabetes. Diabetes Care. 2006 May;29(5):1065-70. [abstract]

Lee JE, Giovannucci E, Smith-Warner SA, Spiegelman D, Willett WC, Curhan GC. Total fluid intake and use of individual beverages and risk of renal cell cancer in two large cohorts. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1204-11. [abstract]

Forman JP, Stampfer MJ, Curhan GC. Diet and lifestyle risk factors associated with incident hypertension in women. JAMA. 2009 Jul 22;302(4):401-11. [abstract]

Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med. 2009 Sep;122(9):857-65. [abstract]>

Taylor EN, Fung TT, Curhan GC. DASH-style diet associates with reduced risk of kidney stones. J Am Soc Nephrol. 2009 Oct;20(10):2253-9. Epub 2009 Aug 13. [abstract]

Curhan SG, Eavey R, Shargorodsky J, Curhan GC. Analgesic use and the risk of hearing loss in men. Am J Med. 2010 Mar;123(3):231-7. [abstract]