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Vincent J. Carey, Ph.D.

Associate Professor of Medicine (Biostatistics)
Harvard Medical School

Associate Biostatistician
Department of Medicine

Brigham and Women's Hospital

Research Interests

Statistical Genomics
Co-founder and core member of the International Bioconductor Project for Statistical Computing in Bioformatics. Bioconductor defines software architecture for various high-throughput experimental platforms, with particular attention to quality control, annotation, and flexible interface to statistical inference tools. The portal now contains hundreds of contributions from research centers all over the world.

Clinical Trials and Longitudinal Data Analysis
I have been principal investigator of statistics and data coordinating centers for AHRQ Pediatric Asthma Care PORT-II, NHLBI Optimal Macronutrient Intake Strategies Against Heart Disease (OMNI Heart Trial), NHLBI Pounds Lost clinical Trial (joint with Pennington Biomedical Research Center, LSU), NHLBI CARB (a new crossover study of effects of diet glycemic index on cardiovascular risk factors) and have been Senior Statistician with the Pediatric AIDS Clinical Trials Group since 1993.

Statistics in Microbiology
I have collaborated with many investigators in the Kasper Lab at Channing. A main contribution has been methodology for inference on the minimum protective antibody level esential in vaccine design.

Statistical Computing
I am associate editor of the Journal of Statistical Software, and of R-News.

Selected Publications

Wang YG, Carey VJ. Unbiased estimating equations from working correlation models for irregularly timed repeated measures. J Amer Stat Assoc 2004; 99:845-53. No abstract available.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zang J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5(10):R80. Epub 2004 Sep 15. [abstract]

Krueger WA, Krueger-Rameck S, Koch S, Carey V, Pier GB, Huebner J. Assessment of the role of antibiotics and enterococcal virulence factors in a mouse model of extraintestinal translocation. Crit Care Med. 2004 Feb;32(2):467-71. [abstract]

Carey VJ, Yong FH, Frenkel LM, McKinney RM. Growth velocity assessment in pediatric AIDS: smoothing, penalized quantile regression and the definition of growth failure. Stat Med. 2004 Feb 15;23(3):509-26. [abstract]

Fuhlbrigge A, Carey VJ, Adams RJ, Finkelstein JA, Lozano P, Weiss ST, Weiss KB. Evaluation of asthma prescription measures and health system performance based on emergency department utilization. Med Care. 2004 May;42(5):465-71. [abstract]

Lozano P, Finkelstein JA, Carey VJ, Wagner EH, Inui TS, Fuhlbrigge AL, Soumerai SB, Sullivan SD, Weiss ST, Weiss KB. A multisite randomized trial of the effects of physician education and organizational change in chronic-asthma care: health outcomes of the Pediatric Asthma Care Patient Outcomes Research Team II Study. Arch Pediatr Adolesc Med. 2004 Sep;158(9):875-83. [abstract]

Carey VJ, Gentry J, Whalen E, Gentleman R. Network structures and algorithms in Bioconductor. Bioinformatics. 2005 Jan 1;21(1):135-6. Epub 2004 Aug 5. [abstract]

Carey VJ, Bishop L, Charleston J, Conlin P, Erlinger T, Laranjo N, McCarron P, Miller E, Rosner B, Swain J, Sacks FM, Appel LJ. Rationale and design of the Optimal Macro-Nutrient Intake Heart Trial to Prevent Heart Disease (OMNI-Heart). Clin Trials. 2005;2(6):529-37. [abstract]

Carey VJ, Pahwa S, Weinberg A. Reliability of CD4 quantitation in human immunodeficiency virus-positive children: implications for definition of immunologic response to highly active antiretroviral therapy. Clin Diagn Lab Immunol. 2005 May;12(5):640-3. [abstract]

Fuhlbrigge AL, Carey VJ, Finkelstein JA, Lozano P, Inui TS, Weiss ST, Weiss KB. Validity of the HEDIS criteria to identify children with persistent asthma and sustained high utilization. Am J Manag Care. 2005 May;11(5):325-30. [abstract]

Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005 May 6;121(3):335-48. [abstract]

Kovacs A., Montepiedra G, Carey VJ, Pahwa S, Weinberg A, Frenkel L, Capparelli E, Mofenson L, Smith E, McIntosh K, Burchett SK; Pediatric AIDS Clinical Trials Group 366 Study Team. Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response. J Infect Dis. 2005 Jul 15;192(2):296-302. Epub 2005 Jun 14. [abstract]

Cohen ND, Carey VJ, Donahue JG, Seahorn JL, Brown SE 2nd, Riddle TW. Temporality of early-term abortions associated with mare reproductive loss syndrome in horses. Am J Vet Res. 2005 Oct;66(10):1792-7. [abstract]

Bricker AL, Carey VJ, Wessels MR. Role of NADase in virulence in experimental invasive group A streptococcal infection. Infect Immun. 2005 Oct;73(10):6562-6. [abstract]

Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER, Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, Charleston J, McCarron P, Bishop LM; OMNI Heart Collaborative Research Group. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA. 2005 Nov 16;294(19):2455-64. [abstract]

Finkelstein JA, Lozano P, Fuhlbrigge AL, Carey VJ, Inui TS, Soumerai SB, Sullivan SD, Wagner EH, Weiss ST, Weiss KB; Pediatric Asthma Care Patient Outcomes Research Team. Practice-level effects of interventions to improve asthma care in primary care settings: the Pediatric Asthma Care Patient Outcomes Research Team. Health Serv Res. 2005 Dec;40(6 Pt 1):1737-57. [abstract]

Reimers M, Carey VJ. Bioconductor: an open source framework for bioinformatics and computational biology. Methods Enzymol. 2006;411:119-34. Review. [abstract]

Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J. Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites. Infection. 2006 Feb;34(1):22-5. [abstract]

Bilban M, Heintel D, Scharl T, Woelfel T, Auer MM, Porpaczy E, Kainz B, Kröber A, Carey VJ, Shehata M, Zielinski C, Pickl W, Stilgenbauer S, Gaiger A, Wagner O, Jäger U; German CLL Study Group. Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression. Leukemia. 2006 Jun;20(6):1080-8. [abstract]

Carey VJ, Morgan M, Falcon S, Lazarus R, Gentleman R. GGtools: analysis of genetics of gene expression in bioconductor. Bioinformatics. 2007 Feb 15;23(4):522-3. Epub 2006 Dec 8. Review. [abstract]