Associated Epidemiologist
Brigham and Women's Hospital

luqi@hsph.harvard.edu

    1)  Genetic epidemiology of diabetes, diabetes-related cardiovascular
       diseases, and obesity

    2)  Nutritional epidemiology and gene-environment interactions of
       diabetes, diabetes-related cardiovascular diseases, and obesity

    3)  Biomarker risk factors for diabetes and cardiovascular diseases

    4)  Lifestyle intervention and metabolic disorders in GDM

    5)  Lifestyle effects on metabolic syndrome and subclinical athrosclerosis

Qi L, Shen H, Tai S, Tan C, Chew S, Greenberg A, Corella D, Ordovas J. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multi-ethnic Asian population. J Mol Med. 2005 Jun;83(6):448-56. Epub 2005 Mar 16. [abstract]

Qi L, Rimm E, Liu S, Rifai N, Hu FB. Dietary glycemic index, glycemic load, cereal fiber and plasma adiponectin concentration in diabetic men. Diabetes Care. 2005 May;28(5):1022-8. [abstract]

Qi L, Li T, Rimm E, Zhang C, Rifai N, Hunter D, Doria A, Hu FB. The +276 polymorphism of the APM1 gene and plasma adiponectin concentration and cardiovascular risk in diabetic men. Diabetes. 2005 May;54(5):1607-10. [abstract]

Corella D, Qi L, Sorli J, Godoy D, Portolés O, Coltell O, Greenberg A, Ordovas J. Obese subjects carrying the 11482G>A polymorphism at the perilipin (PLIN) locus are resistant to weight loss following dietary energy restriction. J Clin Endocrinol Metab. 2005 Sep;90(9):5121-6. Epub 2005 Jun 28. [abstract]

Qi L, Meigs J, Manson J, Ma J, Hunter D, Rifai N, Hu FB. HFE genetic variability, dietary iron intake, body iron stores and the risk of type 2 diabetes in US women. Diabetes. 2005 Dec;54(12):3567-72. [abstract]

Qi L, van Dam R, Mantzoros C, Hu FB. The Association between Whole Grain, Bran, and Cereal Fiber Intakes and Markers of Systemic Inflammation in Diabetic Women. Diabetes Care. 2006 Feb;29(2):207-11. [abstract]

Qi L, Doria A, Manson J, Meigs J, Hunter D, Mantzoros C, Hu FB. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes. 2006 May;55(5):1512-6. [abstract]

Corella D. Qi L, Tai E. Deurenberg-Yap M, Tan C, Chew S, Ordovas J. Perilipin Gene Variation Determines Higher Susceptibility to Insulin Resistance in Asian Women When Consuming a High-Saturated Fat, Low-Carbohydrate Diet. Diabetes Care. 2006 Jun;29(6):1313-9. [abstract]

Qi L, van Dam R, Meigs J, Manson J, Hunter D, Hu FB. IL-6 genetic variability and type 2 diabetes: Large-scale case-control study and meta-analysis. Hum Mol Hum Mol Genet. 2006 Jun 1;15(11):1914-20. Epub 2006 Apr 27. [abstract]

Qi L, Meigs J, Liu S, Manson J, Mantzoros C, Hu FB. Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes. Diabetes Care. 2006 Jul;29(7):1501-5. [abstract]

Zhang C, Qi L, Hunter DJ, Meigs JB, Manson JE, van Dam RM, Hu FB. Variant of transcription factor 7-like 2 (TCF7L2) and the risk of type 2 diabetes mellitus in large cohorts of U.S. men and women. Diabetes. 2006; 55(9):2645-8. [abstract]

Lopez-Garcia E, van Dam R, Qi L, Hu FB. Coffee consumption and markers of inflammation and endothelial dysfunction among healthy and diabetic women. Am J Clin Nutr. 2006 Oct;84(4):888-93. [abstract]

Qi L, van Dam R, Rexrode K, Hu FB. Heme iron from diet as a risk factor for coronary heart disease in women with type 2 diabetes. Diabetes Care. 2007 Jan;30(1):101-6. [abstract]

Qi L, Doria A, Giorgi E, Hu FB. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in US women: A tagging-SNP haplotype analysis. Diabetes. 2007 Jun;56(6):1586-91. Epub 2007 Apr 6. [abstract]

Qi L, Liu S, Rifai N, Hunter D, Hu F. Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL levels in women with type 2 diabetes. Atherosclerosis. 2007 May;192(1):204-10. Epub 2006 Jun 16. [abstract]

Gao X, Qi L, Qiao N, Hyon C, Curhan G, Tucker K, and Ascherio A. Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women. Hypertension. 2007 Aug;50(2):306-12. Epub 2007 Jun 25. [abstract]

Qi L, Zhang C, van Dam R, and Hu FB. Interleukin-6 gene and adiposity: associations in two independent cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab. 2007 Sep;92(9):3618-25. Epub 2007 Jul 10. Review. [abstract]

Qi L, van Dam R, Asselbergs F, and Hu FB. Gene-gene interactions between HNF4A and KCNJ11 in predicting type 2 diabetes among women. Diabet Med. 2007 Nov;24(11):1187-91. Epub 2007 Sep 26. [abstract]

Li T, Zhang C, Qi L, Asselbergs F, Rimm E, Hunter D, Hu FB. Interaction between CETP TaqIB Polymorphism and dietary fat intake on HDL-cholesterol Concentrations in Diabetic Men. Am J Clin Nutr. 2007 Nov;86(5):1524-9. [abstract]

Qi L, Rifai N, Hu FB. Interleukin 6 receptor gene variations, plasma interleukin 6 levels, and type 2 diabetes in US women. Diabetes. 2007 Dec;56(12):3075-81. Epub 2007 Sep 26. [abstract]

Qi L, Zhang C, Greenberg A, Hu F. Common Variations in Perilipin Gene, Central Obesity, and Risk of Type 2 diabetes in US Women. Obesity (Silver Spring). 2008 May;16(5):1061-5. Epub 2008 Mar 6. [abstract]

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL. Association studies involving over 90,000 samples demonstrate that common variants near to MC4R influence fat mass, weight and risk of obesity. Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4. [abstract]

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D. DIAGRAM Consortium. Meta-analysis of genome-wide association data and large-scale replication identifies several additional susceptibility loci for type 2 diabetes. Nat Genet. 2008 May;40(5):638-45. Epub 2008 Mar 30. [abstract]

Qi L, Kang K, Zhang C, van Dam R, Kraft P, Hunter D, Lee CH, Hu FB. FTO Gene Variant Is Associated with Obesity: Longitudinal Analyses of Two Cohort Studies and Functional Test. Diabetes. 2008 Nov;57(11):3145-51. Epub 2008 Jul 22. [abstract]

Qi L, Kraft P, David H, Hu FB. The Common Obesity Variant near MC4R Gene Is Associated with Higher Intakes of Total Energy and Dietary Fat, Weight Change, and Diabetes Risk in Women. Hum Mol Genet. 2008 Nov 15;17(22):3502-8. Epub 2008 Aug 12. [abstract]

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium. GIANT Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14. [abstract]

Qi L, Rifai N, Hu FB. IL6R gene, plasma CRP, and diabetes risk in women. Diabetes. 2009 Jan;58(1):275-8. Epub 2008 Oct 13. [abstract]

Cornelis M, Qi L, Kraft P, Hu FB. TCF7L2, dietary carbohydrate and risk of type 2 diabetes in U.S. women. Am J Clin Nutr. 2009 Apr;89(4):1256-62. Epub 2009 Feb 11. [abstract]

Brennan A, Fargnoli J, Williams C, Li T, Qi L, Kawachi I, Willett W, Hu F, Mantzoros C. Phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes. Diabetes Care. 2009 May;32(5):926-31. Epub 2009 Feb 17. [abstract]

Lin J, Hu FB, Qi L, Curhan GC. Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 daibetes mellitus. BMC Nephrol. 2009 Mar 27;10:9. [abstract]

Qi L, Cornelis M, Zhang C, Van Dam R, Hu FB. Genetic Predisposition, Western Dietary Pattern, and the Risk of Type 2 Diabetes in Men. Am J Clin Nutr. 2009 May;89(5):1453-8. Epub 2009 Mar 11. [abstract]

Cornelis M, Qi L, Zhang C, Kraft P, Manson J, Cai T, Hunter DH, Hu FB. Joint Effects of Common Genetic Variants on the Risk of Type 2 Diabetes in U.S. Men and Women. Ann Intern Med. 2009 Apr 21;150(8):541-50. [abstract]

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium. Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26. [abstract]

Liang J, Xue Y, Zou C, Zhang T, Song H, Qi L. Serum uric acid and prehypertension among Chinese adults. J Hypertens. 2009 Sep;27(9):1761-5. [abstract]

He M, Cornelis M, Franks P, Zhang C, Hu F, Qi L. Obesity Genotype Score and Cardiovascular Risk in Women with Type 2 Diabetes. Arterioscler Thromb Vasc Biol. 2009. No abstract available.

Heid I, … Qi L, .. Wichmann H. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: dose heterogeneity of estimates relate to study design. PLoS Genet, 2009 (in press)

Dupuis J….Qi L,...MAGIC consortium. Novel genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2009. (in press)

Shi Z, Zhou M, Yuan B, Qi L, Dai Y, Luo Y, and Holmboe-Ottesen G. Iron intake and body iron store, anemia, and risk of hyperglycemia among Chinese adults: the prospective Jiansu Nutrition Study (JIN). Public Health Nutrition, 2009 (in press)

Qi L, Chen J. Diet and Genome: the New Frontier for Nutrition Science. Acta Nutrimenta Sinica. 2003; 25(1):1-6

Qi L, Shen H, Ordovas JM. Hearts and bones. Nutr Metab Cardiovasc Dis. 2003;13(3):165-74

Qi L, Hu FB. Influence of Dietary Glycemic Load and Whole Grain Intakes on Systemic Inflammation in Diabetic Patients. Curr Opin Lipidol. 2007; 18(1):3-8.

Qi L, Hu FB, Hu G. Genes, Environment, and Interactions in Prevention of Type 2 Diabetes: a Focus on Physical Activity and Lifestyle Changes. Curr Mol Med. 2008 8(6):519-32.

Qi L. Gene-Diet Interactions and Obesity. Nutrition Reviews. 2008 66(12):684-94.

Qi L. Mendelian Randomization in Nutritional Epidemiology. Nutrition Reviews. 2009 67(8):439-50.